Tuberous sclerosis complex is a multisystemic syndrome that concerns organs and tissues, such as brain, eye, kidney, lung, heart, bone, and skin. It has an autosomal dominant inheritance. The most common involvement in brain is cortical tuber, subependymal nodules, astrocytoma, and white matter. Renal angiomyolipoma, renal cysts, and renal cell carcinoma can be detected in kidneys. Adenoma sebaceum, oral fibrous nodules, periungual fibroma, hypopigmented macules, shagreen patch, acrochordons and tooth enamel is seen in skin. Herein we presented a 13-year-old female patient with brain and renal involvement in addition to skin manifestations that we consider tuberous sclerosis complex. We reviewed the literature accompanying the case.