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Fırat Tıp Dergisi
2018, Cilt 23, Sayı 3, Sayfa(lar) 005-008
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Pathogenesis of Obesity
Zafer PEKKOLAY
Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Endokrinoloji ve Metabolizma Bilim Dalı, Diyarbakır, Türkiye

Obesity is a complex multifactorial disorder that increases the risk of morbidity and mortality, resulting in the accumulation of excess fat in the body, and significantly reduces life expectancy. Obesity is characterized by excessive calorie intake and inadequate calorie expenditure. Obesity is a disease. The Blame may be put on the physiology, but not on the patient. Increased evidence suggests that obesity is merely a disorder of the energy balance system, far from passive accumulation in excess.

Changes in sedentary lifestyle and dietary habits, the association of hypothalamus and gastrointestinal hormones with energy balance, environmental factors, endocrine disruptors, genetics, poor metabolic conditions in intrauterine period, drugs used are the main reasons.

Obesity pathogenesis is not fully understood. Studies to illuminate pathogenesis should be done. Beyond diet and exercise, bad environmental factors and socioeconomic status, endocrine disruptors and sedentary lifestyle lead to obesity risk.


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