Obesity is a complex and multifactorial disease. Together with the increasing prevalence of obesity worldwide among children and adolescents, the need for effective and sustainable treatment has been increasing. An important part of obesity is related to morbidity. Main part of the management of obesity is lifestyle change such as exercise and medical nutrition therapy. Pharmacological treatments can be used, if lifestyle modification recom-mendations are inadequate. Orlistat is not solely sufficient among the current medical treatments. Although the development of new drugs is difficult due to complexity of systemic pharmacotherapies and variables such as ethnicity and age, several drugs are still under development. If safety and long-term effectiveness of these drugs will be proven, promising changes in obesity management are expected.