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Fırat Tıp Dergisi
2022, Cilt 27, Sayı 2, Sayfa(lar) 140-146
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The Frequency of Hepatitis E Virus Infection in Patients Diagnosed with Chronic Hepatitis and Cirrhosis
Sümeyra KAYALI1, Mehmet YALNIZ2, Adnan SEYREK1
1Fırat Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Elazığ, Türkiye
2Fırat Üniversitesi Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Elazığ, Türkiye

Objective: Hepatitis E virus (HEV) is an RNA virus located in the Hepevirus genus of the Hepeviridae family. HEV infection is generally asymptomatic in children and symptomatic in the adult age group in clinic. Although it can be transmitted by consuming undercooked meat of infected animals and blood transfusion, the main transmission route is fecal-oral route. Hepatitis E infection causes adverse outcomes such as acute exacerbations, acute liver damage, decompensation and death in patients diagnosed with chronic hepatitis and cirrhosis. In this study, it was aimed to demonstrate HEV seropositivity and HEV RNA in patients with chronic hepatitis and cirrhosis.

Material and Method: Thirty patients with autoimmune hepatitis, 30 cirrhosis and 40 chronic HBV were included in the study. Anti-HEV IgM and anti-HEV IgG were investigated by micro ELISA and HEV RNA was investigated by RT-PCR in serum samples obtained from these patients.

Results: In the autoimmune hepatitis group, anti-HEV IgM and anti-HEV IgG positivity was observed with a rate of 13%. In the cirrhosis group, 33% anti-HEV IgM and 50% anti-HEV IgG positivity were observed. In the chronic HBV group, 7.5% anti-HEV IgM and 17.5% anti-HEV IgG positivity were observed. HEV RNA could not be detected in any of the patients.

Conclusion: A higher frequency of HEV seropositivity was found in all three patient groups compared to seroprevalence studies reported in our country and province. HEV infection should not be ignored in clinical approaches in patients diagnosed with chronic hepatitis and cirrhosis, and patients should be informed about clean drinking water and well-cooked meat consumption in order to prevent HEV transmission.


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