Nontraumatic Subarachnoid hemorrhage (SAH) is a rare but life-threatening complication in patients undergoing hemodialysis (HD). In this instance, we disclose the occurrence of a nontraumatic SAH in a 28-year-old male patient diagnosed with Familial Mediterranean Fever (FMF) while undergoing HD treatment. The SAH was diagnosed on the basis of clinical and radiological findings. The patient had a history of recurrent attacks of FMF and was undergoing HD for end-stage renal disease (ESRD). The patient was treated with supportive care and close monitoring. Despite all efforts, the patient passed away after 20 days. The cause of SAH in our patient remains unclear, but we think that it is multifactorial in nature and that AA-type amyloidosis may cause this condition with an autoinflammatory reason.