Aim: The aim of the present study is to determine serum changes observed in blood lipids due to isotretionin and asitretin retinoids and to reveal their potential for causing risks in terms of Atherosclerosis (AS) and Coronary artery disease (CAD).

Materials and Method: The study included a total of 40 cases,, whose age ranged between 17 and 55.

Results: It was seen that the increase in lipid levels was dose-dependent and returned to normal after treatment.

Conclusion: In our study, increases in serum levels of LDL (low density lipoprotein), and Lipoprotein (a) (Lp(a)) were parallel. When the serum levels of these two lipids, each of which is an individual risk factor for AS and CAD, are high, the risk of AS and CAD development increases.