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Fırat Tıp Dergisi
2005, Cilt 10, Sayı 3, Sayfa(lar) 117-122
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Oxidant and Antioxidant Status in Type 2 Diabetic Patients Before and After Therapy
İhsan HALİFEOĞLU1, Fikret KARATAŞ2, Ramis ÇOLAK3, Halit CANATAN4, Selda TELO1
1 Fırat Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, ELAZIĞ
2 Fırat Üniversitesi Fen-Edebiyat Fakültesi Kimya Bölümü, ELAZIĞ
3 Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, ELAZIĞ
4 Fırat Üniversitesi Tıp Fakültesi Tıbbi Biyolojiı Anabilim Dalı, ELAZIĞ

Several studies reported that diabetic vascular complications and lipid peroxidation occur due to high blood glucose levels. Aim of the present study was to evaluate antioxidant status in type 2 diabetics (DM) before and after therapy. Levels of serum fasting glucose, malondialdehyde (MDA), lycopene, antioxidant vitamins (A, E, and C), triglycerid, total cholesterol, HDL- cholesterol, LDL- cholesterol, as well as eritrocyte HbA1C levels along with enzyme acitivity levels of superoxide dismutase (SOD), catalase (CAT) ve glutathion peroksidase (GSH-Px) were determined in thirty type 2 diabetic patients (19 man, 11 woman). After treatment period, reduction in blood glucose levels was accompanied with significant reduction in levels of HbA1C, MDA and triglycerid whereas there was significant increase in levels of CAT, SOD, vitamin A ve vitamin E. There was no statistically significant changes in levels of GSH-Px, vitamin C, lycopene, total cholesterol, HDL- cholesterol, LDL- cholesterol. Present results indicate that oxidative status developed due to hyperglycemia can be normalized by treatment. Treatment of diabetics who are educated by their attending doctors regarding their sickness will be much easier, this will affect the quality of diabetics positively, as a result financial burden on individuals and country will be minimized. ©2005, Fırat Üniversitesi, Tıp Fakültesi

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