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Fırat Tıp Dergisi
2005, Cilt 10, Sayı 3, Sayfa(lar) 127-131
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Acute Disseminated Encephalomyelitis: Clinical Series
Nimet KABAKU, Ayşegül Neşe ÇITAK KURT
Fırat Üniversitesi Tıp Fakültesi Pediatri Anabilim Dalı, ELAZIĞ

Objectives: Acute disseminated encephalomyelitis is typically a monophasic, demyelinating disease of the central nervous system that predominantly affects children. The work was done to describe the epidemiologic, clinical, neuroimaging and laboratory features; treatmet and outcome in children with Acute disseminated encephalomyelitis.

Materials and Methods: Ten children with acute disseminated encephalomyelitis were seen at the Firat University Pediatric Neurology Unit over a five year period (July 1999-June 2005). Diagnosis was based upon typical clinical features and characteristic findings on neuroimaging. Cerebrospinal fluid examination and other investigations were done, where appropriate, to rule out other causes of central nervous system disease.

Results: Six children had a prodromal illness. The most common presenting symptoms were ataxia, dysarthria and seizures. All children had an abnormal neurological examination. In the first administration, only three patients had hyperintense signals on brain magnetic resonance imaging. All children were treated with methylprednisolone, one child with optic neuritis received both methylprednisolone and immunoglobulins Patients who had more than one relapse (n = 2) presented with new symptoms at each attack. Of 10 children, 80 % recovered completely, but the patients who had more than one relapse has severe disability (hemiparesis and optic atrophy).

Conclusion: Although in the cases of acute disseminated encephalomyelitis complete clinical recovery is common, serious neurological complications are also seen in childhood The timing and duration of steroid treatment affects outcome. ©2005, Fırat Üniversitesi, Tıp Fakültesi


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