We present a 77-year woman with a size of 9.5x9x7cm giant ancient schwannoma located in the lower arm. Increased activity accumulation in the tumor was seen on the Tc-99m-methylene diphosphonate bone scintigraphy. After excision of the tumor, Pathologic diagnosis could be illustrated as an ancient schwannoma. Previous studies reported that Schwannoma could be demonstrated with increased Tc-99m-diphosphonates activity accumulation but we speculate that this accumulation may be related to tissue types or atypical types of schwannoma. ©2006, Fırat Üniversitesi, Tıp Fakültesi