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Fırat Tıp Dergisi
2006, Cilt 11, Sayı 2, Sayfa(lar) 093-097
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Value of GLUT-1 and Ki-67 in Differential Diagnosis in Benign, Premalign and Malign Lesions of Endometrium
Adile Ferda DAĞLI, Mehmet Reşat ÖZERCAN
Fırat Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, ELAZIĞ

Objectives: Endometrial carcinoma is the fourth most frequently diagnosed cancer in women. For this reason, the early diagnosis of premalignant lesion of endometrium is very important and it is tried to determine the risk and prognostic factors. The objective of this study was to determine relationship between immunohistochemical markers such as GLUT-1, Ki-67 and benign, premalign, malign lesions of endometrium.

Materials and Methods: A total of 100 specimens were retrieved from the archives of the Pathology Department, Firat Medical Center of Firat University. These specimens were containing: 20 proliferative endometrium, 20 secretory endometrium, 20 simple hyperplasia, 20 complex hyperplasia, 20 endometrioid carcinoma. All specimens were stained immunohistochemically with GLUT-1 and Ki-67. Placenta and tonsile tissue was used as positive control specimen for GLUT-1 and Ki-67 respectively. Cells were considered positive only when cytoplasmic staining by GLUT- 1 and nuclear staining by Ki-67 was observed.

Results: Intensity of GLUT-1 staining shows progresively more staining in endometrioid carcinoma as compared to proliferative endometrium, secretory endometrium and hyperplasia. Mean Ki-67 values were also higher in cases with endometrioid carcinoma (47.96±5.84) compared with those cases with proliferative endometrium (32.90±7.16), secretory endometrium (16.64±9.01), simple hyperplasia (32.28±5.60), complex hyperplasia (35.65±4.33). The relationships between GLUT-1 positivity and Ki-67 PI were found meaningful in similar cases.

Conclusion: As in a conclusion, GLUT-1 immunstaining and Ki-67 PI may be useful in distinguishing benign lesions from premalign and malign lesion. ©2006, Fırat Üniversitesi, Tıp Fakültesi


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