Objectives: Determination of prescense of genital mycoplasma and/or ureaplasma in patients with long lasting vaginal discharge and evaluation of their antimicrobial susceptibilities.

Materials and Methods: Endocervical swabs of 130 sexually active women (18-41 years) with complaints of vaginal discharge for more than seven days, and without a history of antibiotic usage within the last month, were investigated prospectively. Specimens were taken with Dacron swabs and evaluated with Mycofast Screening Evolution 2 Test (International Microbio, France) for the presence of Mycoplasma hominis and Ureaplasma urealyticum.

Results: There wasn’t any growth in 72 (55.38 %) of patients, but in 51 (39.23 %) patients U. urealyticum and in 7 (5.38 %) patients M. hominis were identified. Cervical swabs of 40 healthy women aged between 20-45 years who didn’t have vaginal discharge were taken as control group. In the control group, 35 (87.5 %) of 40 specimens showed no growth and in 5 (12.5 %) specimens U. urealyticum were identified. The statistical analysis of our results yielded that there was no statistically significant difference between study and control groups regarding the growth of M. hominis (p>0.05), but the growth of U. urealyticum was significantly higher in the study group (p=0.001).

Conculation: All of the U. urealyticum isolates recovered from study and control groups were susceptible to doxycycline, roxithromycin, and ofloxacin. All isolates of M. hominis were susceptible to doxycycline, but they were 57.1% and 28.5% resistant to roxithromycin and ofloxacin, respectively. As result, in patients with a vaginal discharge for more than 7 days, U. M. hominis be taken into consideration as the causative agent of cervical infection.©2006, Fırat Üniversitesi, Tıp Fakültesi