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Fırat Tıp Dergisi
2004, Cilt 9, Sayı 1, Sayfa(lar) 15-17
[ Turkish ] [ Tam Metin ] [ PDF ]
The Effect of Pseudoephedrine In the Medical Treatment of Male Infertility
İrfan ORHAN1, Rahmi ONUR1, Atilla SEMERCİÖZ1, Veysel YÜZGEÇ1, Ali ERDİNÇ2
1 Fırat Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı
2Fırat Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı ELAZIĞ

Objective: To investigate the activity of a sympathomimetic drug pseudoephedrine in the medical treatment of male infertility.

Materials and Method: Fifty- two sub-fertile patients whom were referred to our clinic due to infertility and with out any determined infertility pathologies in fertility assessments were retrospectively investigated. As a sympathomimetic agent 180 mg pseudoephedrine was administered to 34 patients for a period of one month. No other drugs were administered to the remaining 18 patients; these patients were the group waiting for assistive reproduction techniques. Patients were assessed according to pre- and post-therapeutic ejaculate volume, total motile sperm number and pregnancy.

Results: A significant increase was determined in the ejaculate volume in the group of patients whom were treated with pseudoephedrine while no significant differences were found among patients included in both of the both groups regarding the pre- and post-therapeutic testis volumes, hormone parameters, total motile sperm number, and ratio of pregnancies (p<0,001). No any significant increases were determined in the total motile sperm number in the therapy group; however, the ratio of improvement were more significant when compared with the followed group (p<0,01). The didn’t obtain spontaneus pregnancy in neither treatment group nor control group.

Conclusion : The manipulation of the sympathetic system by miscellaneous selective drugs that provide a major innervation in the males reproductive system may allow us to treat possible neuro-myogenic pathologies in idiopathic infertile patients which are currently undiagnosed.


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