Objectives: Aim of this study is to determine serum levels of paraoxonase (PON), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamil transferase (GGT) at 6th and 24th hour after the intake of poisonous substances and to investigate the role of these parameters in the follow up and treatment of the patients and the correlation between them.

Material and Methods: The study was performed in the emergency department of Firat University Faculty of Medicine between the dates of December 2003 and June 2004 with 82 poisoning patients older than 16 years and matching inclusion criteria prospectively.

Results: Eighty-two patients were included to the study. Mean MDA1 and MDA2 levels of these patients were 0.39±0.2 and 0.45±0.3 mmol/mL respectively. Mean PON1-1 and PON1-2 levels were 153.33±77.3 and 146.25±70.7 U/mL respectively. Mean AST1, AST2, ALT1, ALT2, GGT1 and GGT2 levels were 21.53±8.1, 26.73±47.7, 20.16±9.6, 20.87±21.6, 20.75±15.3 and 20.77±20.0 U/L respectively. No statistically significant difference was found among the patients taking tricyclic antidepressants, acetaminophen, mushroom, alcohol, and organophosphates according to serum levels of MDA, PON1, AST, ALT and GGT.

Conclusion: We think that the values of MDA, PON1, AST, ALT and GGT at 6th and 24th hour have no role in first 24 hour follow up and treatment of acute poisoning patients. New laboratory parameters may be investigated for the follow up and treatment of poisonings, which are important health problems. ©2007, Firat University, Medical Faculty