Hypertensive encephalopathy is an acute organic cerebral syndrome which occurs when the elevation in the blood pressure exceeds the limit of cerebral vascular auto regulation. Alterations resulting from vasogenic edema affecting cortical and sub cortical white matter areas, especially in the parietal-occipital lobes are observed in the radiological imaging. Involvement of brainstem, basal ganglia and cerebellum is infrequent, if involved it occurs usually in association with the parietal-occipital white matter changes. In this study, clinical, laboratory, computed tomography and magnetic resonance imaging findings of a case with atypical hypertensive encephalopathy involving predominantly the frontal-temporal areas in the radiological evaluations were presented and the differential diagnosis was discussed in the light of literature. ©2007, Firat University, Medical Faculty