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Fırat Tıp Dergisi
2008, Cilt 13, Sayı 1, Sayfa(lar) 005-008
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EGCg Supplementation Improves Oxidant and Antioxidant Status in Kidney of Rats Exposed to Sevoflurane
Ayşe Belin ÖZER1, Dilara KAMAN2, Ömer Lütfi ERHAN3, Songül ÖZER4
1Mardin Devlet Hastanesi, Anestezi Uzmanı, MARDİN
2Fırat Üniversitesi, Tıp Fakültesi Tıbbi Biyokimya Anabilim Dalı, ELAZIĞ
3Fırat Üniversitesi, Tıp Fakültesi Anesteziyoloji Anabilim Dalı, ELAZIĞ
4Fırat Üniversitesi, Veteriner Fakültesi Patoloji Anabilim Dalı, ELAZIĞ

Objectives: To investigate the possible effects of sevoflurane anesthesia and epigallocatechin 3- gallate (EGCg) on kidney tissue by evaluating the oxidant and antioxidant status in rats.

Materials and Methods: Tree groups of animals were studied. Sevoflurane 3% (v/v) in air/O2 were administered to animals in group 1 (n = 7) and sevoflurane plus EGCg was administered in group 2 (n = 7). Seven animals were allocated to control group (group 3). Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in kidney tissue were studied. Histopathological changes were also assessed.

Results: In group I, MDA, NO, SOD and GSH-Px activities were increased while decreased CAT activities occurred when sevoflurane was exposured compared with controls. Supplementation of EGCg (group 2) decreased the MDA (P<0.05), SOD (P<0.005) and GSH-Px activities whereas, the NO (P<0.005) and CAT (P<0.005) activities increase with EGCg supplementation compared with group 1. In histopathology, sevoflurane exposure group had severe degeneration with moderate cortical necrosis in kidney tissue. Administration EGCg with sevoflurane exposure decreased degeneration.

Conclusion: The amount of lipid peroxidation and antioxidant enzyme levels were more increased in following sevoflurane administration. The administration of EGCg significantly protected kidney tissue. ©2008, Firat University, Medical Faculty


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