Cardiopulmonary function in patients with chronic thromboembolic pulmonary hypertension can be normalized by pulmonary endarterectomy. Pulmonary thromboendarterectomy (PTE) is likely that organized fibrous materials have taken out with during cardiopulmonary bypass. It has high mortality. We aimed to present a case of pulmonary endarterectomy following chronic thromboembolic pulmonary hypertension due to deep venous thrombosis before 6 years ago, who is 28 years old-male, in this paper. First, a tissue-plasminogen activator was used because of high surgical mortality. As clinic situation did not relieve, PTE was performed in the patient. All data improved in early postoperative period and after pump. Nevertheless the state of pulmonary edema progressed in the 4th hour of postoperative period approximately. Although additional medical treatment, the clinical situation of patient impaired again in the 12th hour of postoperative period. The patient was expired due to cardiac arrest. We think that surgical mortality will be decreased by obtained clinical experience with such surgical interventions. ©2008, Firat University, Medical Faculty