Primary pyomyositis is the pyogenic infection of the skeleton muscle. While it is often seen in tropical and subtropical regions, it is rare in temperate regions. In this study, two incidents were discussed. One of them was in the adductor muscle group in left thigh developed due to Staphylococcus aureus, and the other incident was a rarely seen primary pyomyositis localized to the biceps muscle. In the first case, 72-year-old male patient complained that he had mass and pain in his left thigh. The second case, an 11-year-old girl, was consulted to our clinic owing to the pain in her left arm and restriction on her elbow mobility without a trauma history. Findings were evaluated in clinical, laboratory and radiological aspects. In the aspiration of the muscles, yellow purulent fluid was aspired. She was clinically diagnosed with primary pyomyositis. Following the surgical drainage, anti-biotic treatment was started. After the operation, an improvement in the clinical symptoms and laboratory values of the patients were determined.©2008, Firat University, Medical Faculty.