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Fırat Tıp Dergisi
2009, Cilt 14, Sayı 3, Sayfa(lar) 167-170
[ Turkish ] [ Tam Metin ] [ PDF ]
Effects of Electroconvulsive Therapy on Sympathetic Skin Responses in Patients with Major Depression
Caner Feyzi DEMİR1, Rabia BİLİCİ2, Hasan Hüseyin ÖZDEMİR3, Said BERİLGEN3
1Elazığ Eğitim ve Araştırma Hastanesi, Nöroloji Anabilim Dalı, ELAZIĞ, Türkiye
2Elazığ Ruh ve Sinir Hastalıkları Hastanesi, Psikiyatri Anabilim Dalı, ELAZIĞ, Türkiye
3Fırat Üniversitesi Eğitim ve Araştırma Hastanesi, Nöroloji Anabilim Dalı, ELAZIĞ, Türkiye

Objective: Depressed patients frequently complain about vegetative symptoms. The relation between depression and disturbances of autonomic regulation has been recognised for a long time. The aim of this study was to investigate whether sympathetic skin responses (SSRs) were affected by electroconvulsive therapy (ECT) in patients with major depression. Materials and Methods: In our study we examined 40 patients diagnosed with major depression who would take ECT during a course of treatment and 30 age-matched healthy subjects. Sympathetic skin responses were assesed on the same day before and after the ECT. Pre-ECT, post-ECT, and control groups' measurements of SSR were compared by non-parametric tests. Results: The mean post-ECT latency of SSR (1.25±0.11 ms) was statistically significantly different (p <0.05) compared with pre-ECT latency of SSR (1.26± 0.11 ms) in patients with major depression. This result demonstrates a relation between SSR and ECT in patients with major depression. However there was no significant difference in SSR latency between patients (pre-ECT and post-ECT) and controls (1.22±0.08 ms). There was no statistically difference also in SSR amplitude among three groups. Conclusion: Data reported in this article support that activation of sympathetic system by ECT treatment does not have a major efficacy in patients with major depression. More studies are needed to evaluate the effects of depression treatment with ECT on SSR.

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