Multiple sclerosis (MS) causes functional loss in different areas of central nervous system and, various clinical findings. Progress of MS could distinguish in same patient in different times as well as among different patients. We presented a female patient with diagnosed MS in 60 years old. Her complaints began in good clinical progress in young adult life. She had been observed prominent progression in clinical course after 58 years old. The aim of this article to discuss the choices of diagnosis and treatment in patients advanced ages.