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Fırat Tıp Dergisi
2010, Cilt 15, Sayı 1, Sayfa(lar) 031-033
[ Turkish ] [ Tam Metin ] [ PDF ]
Prenatal Diagnosis and Management of Orofacial Clefts
Miğraci TOSUN, Burcu TORUMTAY, Devran BILDIRCIN, Handan ÇELİK, Mehmet B. ÇETİNKAYA, Erdal MALATYALIOĞLU
Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kurupelit / SAMSUN, Türkiye

Objective: To evaluate the fetuses in which cleft lips/palates were detected.

Materials and Methods: The fetuses in which cleft lip/palate detected in Ondokuz Mayis University, Medical Faculty, Obstetrics and Gynecology Policlinics, between January and- December 2008, were examined.

Results: A total of eight fetuses were evaluated. There was smoking in only one case as a risk factor. Unilateral cleft lip/palate in four, bilateral cleft lip/palate in three and median cleft lip/palate in one case were detected, respectively. Of four patients who accepted to have karyotype analysis, two had normal karyotype and the other had 46,XY,der(15)t(10;15)(q22.2;q11.2) pat karyotype. The fourth patient had 46,XY karyotype although female phenotype was depicted by ultrasonography. Single umblical cord, agenesis of cerebellar vermis, ventriculomegali and Fallot Tetrology were identified as additional anomalies.

Conclusion: Karyotype analysis, fetal echocardiography and detailed ultrasonography to investigate additional anomalies should be performed in cases in which cleft lip/palate were detected.


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