Objective: The aim of this study was to evaluate the relationship between serum GGT levels and liver fibrosis among patients with chronic hepatitis B in Fırat University Medical School.

Materials and Methods: In Gastroenterology Clinics of Fırat University Medical School, data regarding 140 chronic hepatitis B patients and laboratory results were analysed retrospectively. All patients had undergone liver biopsies and according to histopathological stages of fibrosis (Knodell's classification), they were classified as mild (stage 0-2) and severe (stage 3-4) fibrosis groups. The groups were compared to each other in terms of serum GGT levels.

Results: When compared to severe fibrosis group, mild fibrosis group had no statistical difference in terms of serum fasting glucose, bilirubin, ALP, T.protein, PT, Hb, HBsAg titer and HBV DNA levels. On the other hand there were statistically significant differences between groups in terms of age, AST, ALT, platelets and albumin levels. Mild fibrosis group had a mean GGT level of 39.33±26.01 while severe fibrosis group had a mean GGT level of 66.19±67.69. The difference between groups in terms of GGT levels was significant (p=0.002).

Conclusion: In chronic hepatitis B patients high serum GGT levels seem to be related to higher stages of fibrosis in liver biopsies. Elevetad GGT level in our patients is in parallel to older age, high ALT and AST, low platelets and albumin. GGT may be a non invasive marker of fibrosis in chronic hepatitis B patients.