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Fırat Tıp Dergisi
2011, Cilt 16, Sayı 2, Sayfa(lar) 102-105
[ Turkish ] [ Tam Metin ] [ PDF ]
Leigh Syndrome: Cranial MRI and MR Spectroscopy Findings
Hasan AYDIN, Volkan KIZILGÖZ, Baki HEKİMOĞLU
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Radyoloji Anabilim Dalı, Ankara

A 10 years old girl, was admitted to the intensive care unit with seizure, myotonic-clonic jerks in her hands, vomiting, respiratory failure and mild metabolic acidosis. Brain Magnetic resonance imaging (MRI) and proton MR spectroscopy(MRS) were performed.The MRI findings presented symmetric basal ganglia, brain stem, left thalamus and subthalamic nuclei involvement. MRS obtained from the basal ganglia and thalamus lesions, showed increased lactate and choline peak, decreased NAA\Crea and NAA\Cho ratios. In the CSF, there was also increased lactate. These imaging findings, clinical course and the laboratory data were used for the diagnosis of Juvenile form of Leigh syndrome. Muscle biopsy wasn't needed for the diagnosis.

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