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Fırat Tıp Dergisi
2011, Cilt 16, Sayı 3, Sayfa(lar) 125-128
[ Turkish ] [ Tam Metin ] [ PDF ]
Inducible Beta-Lactamase Activity of Nosocomial Pseudomonas Aeruginosa Strains
Mustafa BERKTAŞ1, Hüseyin GÜDÜCÜOĞLU1, Aytekin ÇIKMAN1, Mehmet PARLAK1, Görkem YAMAN2
1Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Van, Türkiye
2Acıbadem Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye

Objective: Inducible beta-lactamase (IBL) presenting Pseudomonas aeruginosa strains can lead to inadequate treatment because of resistance to many beta-lactam antibiotics and cause serious clinical problems. In this study, we aimed to determine the presence of IBL and antibiotic resistance rates of nosocomial Pseudomonas aeruginosa strains.

Materials and Methods: The IBL production were investigated in 87 P. aeruginosa strains which were isolated between October 2008 and November 2009 in our laboratory and defined as nosocomial isolates according to CDC criteria. Susceptibility testing of antipseudomonal antibiotics were performed with Phoenix automated microbiology system (Becton-Dickinson, USA).

Results: Among 87 strains isolated from various clinical specimens 64 (74%) P. aeruginosa strains were detected positive for IBL production. Resistance rates for antipseudomonal antibiotics were 11% to amikacin, 38% to ciprofloxacin, 47% to ceftazidime, 51% to levofloxacin, 60% to meropenem, 66% to piperacillin-tazobactam, 71% to imipenem and gentamicin, 72% to aztreonam, 74% to piperacillin, and 76% to cefepime.

Conclusion: Because of high incidence of IBL production and antibiotic resistance of P. aeruginosa strains in our hospital, these findings be taken into account can be benefit when planning empirical therapy.


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