An eight-year-old girl patient was admitted to hospital with generalized tonic-clonic seizure without fever. It was established from the patient's medical history that she was using imipramine 10 mg (0.41 mg/kg/day) for a duration of 20 days for enuresis nocturna. There was no specialty in the personal or family history. Her physical examination was normal. The serum electrolytes, liver function tests, renal function tests and brain magnetic resonance imaging were normal. The patient's seizure was considered to be linked to imipramine. Imipramine was stopped. The patient is being follow-up for six months without receiving anticonvulsant therapy. With this case, we would like to emphasize that imipramine could have caused the convulsion.