Objective: Streptococcus pneumoniae is an important cause of morbidity and mortality because of the increasing antibiotic resistance. In this study we aimed to determine resistance rates of Streptococcus pneumoniae strains to various antibiotics.

Materials and Methods: A total of 80 S.pneumoniae strains isolated from various clinical specimens were examined. Identification and antibiotic susceptibility testing of microorganisms thought to be S.pneumoniae with conventional methods was performed by BD Phoenix automated microbiology system (Becton Dickinson, USA) and its panels of streptococci. Antibiotics were evaluated based on manual of Clinical and Laboratory Standards Institute (CLSI) 2010 drug groupings.

Results: Antibiotic resistance rates of S.pneumoniae strains were 33% to erythromycin, 25% to tetracycline, 21% to trimethoprim-sulfamethoxazole, 14% to clindamycin, 8% to penicillin, 8% to meropenem, 6% to cefepime, 5% to chloramphenicol, 5% to amoxicillin, %5 to telithromycin, 4% to levofloxacin, 4% to moxifloxacin and 3% to cefotaxime, respectively. All strains were sensitive to linezolid and vancomycin.

Conclusion: Antibiotic resistance rates of the antibiotics recommended for the treatment of infections caused by S. Pneumonie were found low.