Although the rate of mortality and morbidity of acute pancreatitis has been reduced significantly parallel to the developments in the diagnosis and treatment, it is still high and constituting a challenging problem. Abdominal compartment syndrome (ACS), one of the important complications of the acute pancreatitis can cause multiple organ failure and death by increasing intra-abdominal pressure, splanchnic and intestinal hypoperfusion. The aim of presenting this case that developed multiple organ failure due to ACS caused by acute pancreatitis is to emphasize those patients with acute pancreatitis need to be trated carefully in terms of ACS because of its high mortality ratio.