Objective: The aim of this study was to examine the relationship between Platelet Function Analyzer-200 (PFA-200) test and Child-Pugh, MELD and Na-MELD scores in patients with liver cirrhosis, regardless of etiology, and to investigate the usability of PFA-200 test alone as a prognostic indicator.

Material and Method: Fifty patients with liver cirrhosis at different stages who were hospitalized in our clinic between August 2016 and January 2017 were included in this study. Child-Pugh, MELD and Na-MELD scores of the patients were calculated and divided into groups according to these prognostic scores. The correlation between Collagen/ADP (Chol/ADP) and Collagen/Epinephrine (Col-Epi) values measured with PFA-200 and prognostic scores was examined.

Results: The mean PFA Col/ADP time of the patients was 173.44±81.79 seconds, 38% (n =19) had normal and 62% (n =31) had high closure time. The mean PFA Col/Epi time of the patients was 181.06±68.81 seconds, 46% (n =23) had normal and 54% (n =27) had high. When the relationship between closure times and platelet levels was examined; platelet levels were found to be lower in those with high closure times, but this difference was not statistically significant. No significant difference was found when the closure times of Child-Pugh A, B, C groups were compared. Similarly, there was no significant difference between the groups classified as mild, moderate, and high according to MELD and Na-MELD scores.

Conclusion: The clinical benefit of using Col/ADP and Col-Epi tests as mortality and prognosis indicators in patients with liver cirrhosis was not determined.