Squmaous cell carcinoma is a very rare clinical condition encountered as a complication of chronic osteomyelitis. Chronic osteomyelitis is a serious complication of fractures or crush injuries that has to be treated appropriately. Similarly, squamous cell carcinoma is considered as the last complication that has been considered by most of the orthopaedists. In this case report, it was aimed to highlight the importance of correct diagnosis and treatment of both chronic osteomyelitis an done of its complication squamous cell carcinoma.