Objective: The aim of this study was to evaluate the clinical characteristics and follow-up findings of children with levothyroxine poisoning.

Material and Method: Children with levothyroxine poisoning in four pediatric endocrinology clinics in different provinces in our country between May 2013 and December 2018 were evaluated retrospectively from hospital records. Demographic characteristics of the cases, complaints on admission, vital signs, levothyroxine poisoning dose, laboratory findings, treatments applied, thyroid function tests in the follow-up and observed complications were recorded.

Results: Data of 12 patients, 7 of whom were girls, with a median age of 5.4 years (1.5-17.0) were analyzed. 5 of the cases were in the adolescent age group and 4 of them used levothyroxine for suicide attempt and one for weight loss. It was observed that the mean poisoning dose was 3.1±2.0 mg (0.3-6.0) levothyroxine. Six patients had no clinical findings at presentation. The main symptoms observed were restlessness, palpitations, sweating, vomiting, lethargy, seizures, speech and gait disturbance. Activated charcoal was given to all patients after gastric lavage. Some cases were additionally treated with steroids, propranolol, or cholestyramine. None of the patients required plasmapheresis and hemodialysis. The patients were followed up for a median of 7 days (3-30). Two patients had shortterm supraventricular tachycardia and one patient had acute renal failure.

Conclusion: Although the majority of levothyroxine poisonings in children are untreated or only supportive and symptomatic treatment is sufficient, specific treatment and follow-up should be planned for each patient in terms of the risk of serious complications.