Multiple sclerosis (MS), is a chronic demyelinating relapsing-remitting disease of central nervous system. In the etiopatogenesis, autoimmunity to myelin plays role. In MS, ocular motor sings are not rare. Internucleer ophthalmoplegia is the most common horizontal gaze disorder in MS patients however sixth nerve palsy is not rare. In acquired cranial ocular nerve palsies, diplopia is an important symptom. However in our forty one-year-old MS patient, with sixth nerve palsy, diplopia symptom was not present. The reason is central scotoma in the left eye. We should keep in mind that during the ocular movement examination of MS patients, diplopia may not be reported because of optic neuritis squeal. ©2008, Firat University, Medical Faculty