Objective: The demographic and clinical characteristics of the symptomatic epilepsy patients followed up at the epilepsy clinic of Harran University Faculty of Medicine were investigated and the efficacy of prospective follow-up on epilepsy polyclinic was evaluated.

< b>Material and Method: 210 of patients treated at the epilepsy outpatient clinic between September 2015- June 2016 were evaluated retrospectively and 44 patients with suspected symptomatic epilepsy and a structural lesion that increased the risk of seizure on brain imaging were included in the study.

Results: Five patients (11.4%) had cortical developmental malformation , 3 (6.8%) neurocutaneous syndrome, 5 (11.4) tumor, 10 (22.7%) head trauma, 10 (22.7%) perinatal injury, 8 (18.2%) encephalomalacia, 2 (4.5%) encephalitis sequelae and 1 (2.3%) patient with mesial temporal sclerosis. The seizures of 10 patients were under control when they applied to our epilepsy outpatient clinic. The treatment of 34 (81.8%) patients whose seizures were not under control was changed. 21 of them (47.7%) had only drug dose increase, 7 (15.9%) both new drug addition and current antiepileptic dose increase, and 6 (13.6%) only new drug addition. 12 (28.9%) patients had seizure control. 12 (26.7%) patients had more than 50% reduction in seizure frequency and 7 (17.8%) patients had less than 50% reduction. Seizures of 1 (2.2%) patient did not change. 15 (34.1%) patients were evaluated as drug resistant epilepsy.

< b> Conclusion: Regular follow-up from epilepsy polyclinic and the regulation of drug treatment have positive effects on seizure control in symptomatic epilepsy patients with treatment-resistant epilepsy.