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Fırat Tıp Dergisi
2006, Cilt 11, Sayı 1, Sayfa(lar) 040-044
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The Efficiency of Omega-3 Fatty Acid (Fish Oil) in Hyperlipidemia Treatment
Yusuf ÖZKAN1, Süleyman Serdar KOCA2
1Fırat Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı, ELAZIĞ
2Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, ELAZIĞ

Objectives: Such atherosclerosis-based diseases like coronary artery disease, myocardial infarction, and stroke are leading causes of morbidity and mortality. Hyperlipidemia is among the major risk factors for atherosclerotic diseases and results in accelerated atherosclerosis. Omega-3 fatty acids were reported to favorable effects on lipid profile, inflammation and blood pressure and to reduce rates of mortality associated with cardiovascular diseases. In this study we aimed to examine the effect of omega-3 fatty acid on lipid profile by comparing it with atorvastatin.

Materials and Methods: The study registered 41 hyperlipidemic patients. The patients were randomized to two groups: the first group (n=20) was treated with 3 x 500 mg fish oil and the second group (n=21) with 20 mg/day atorvastatin. Serum lipid levels were examined and compared at the beginning of the treatment and in the third month.

Results: It was observed that fish oil reduced total cholesterol by 19.2%, LDL by 21.2% and triglyceride by 21.2%, while atorvastatin treatment led to a decrease of 29.8% in total cholesterol, 26.8% in LDL and 25.9% in triglyceride. There was no statistically significant difference between the decreases in serum lipid levels of the groups. Although atorvastatin treatment did not change HDL levels, fish oil treatment brought about an increase in HDL levels. Blood pressures significantly decreased as a result of the treatment in both groups, but the increase in the fish oil group was more pronounced.

Conclusion: Fish oil decreases total cholesterol, LDL and particularly triglyceride, levels, while increasing HDL levels. ©2006, Fırat Üniversitesi, Tıp Fakültesi

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