Familial multiple lipomatosis (FML) occurring in an individual without apparent cause may be a separate disease entity or it may be a manifestation of the familial form where the family is too small to show other affected members. In this study we presented the cases of two operated brothers with FML. They were aged 61 and 47, had swelling and pain on arms, body and thigh, and difficulty in dressing. Clinical features, genetic evidence and treatment options are reviewed.