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Fırat Tıp Dergisi
2011, Cilt 16, Sayı 2, Sayfa(lar) 046-050
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The Investigation Effects of Enalapril and Losartan on The Renal Tissues of The Experimental Diabetic Rats
Mehmet Murat DOĞAN1, Emir DÖNDER1, Tuncay KULOĞLU2, Dürrin Özlem DABAK2
1Fırat Üniversitesi, İç Hastalıkları Anabilim Dalı, Elazığ, Türkiye
2Fırat Üniversitesi, Histoloji ve Embriyoloji Anabilim Dalı, Elazığ, Türkiye

Objective: The aim of this study was to determine the effects of Enalapril and Losartan on renal tissues of Streptozocin(STZ)-induced diabetic rats.

Materials and Methods: 28 Wistar rats were used in this study. All rats were divided into 4 groups as control group (n=7), diabetic group (n=7), DM+ Enalapril (n=7) and DM+ Losartan group (n=7). 50 mg/kg STZ administered intraperitoneally to diabetic, DM+ Enalapril, DM+ Losartan groups. Five mg/kg/day Enalapril and 10 mg/kg/day Losartan were orally administered to treatment group from the begining of the diabetes. At the end of fourth week all rats were decapitated and renal tissues were removed. Tissue samples were processed by using routine paraffin techniques. Paraffin sections were stained with periodic-acid-schiff (PAS).

Results: Glomerules and tubules of control group were normal. In diabetic group; narrowing in Bowman spaces of some glomeruli, mesangial matrix enlargement and tubular dilatations were determined. Additionally; loosing of brush like edges of tubular epithelial cells, falling of the cells to the lumene of tubules, thickening of tubular basement membrane and Armanni-Ebstein lesions were determined. The histologic appearance of DM+ Enalapril and DM+ Losartan groups were similar. There were narrowing in Bowman spaces, mesangial matrix enlargement and thickening of tubular basement membranes. Tubular dilatation and Armanni-Ebstein lesions were less remarkable than diabetic group. Loosing of brush like edges of tubular epithelial cells were decreased.

Conclusıons: It was determined that enalapril and losartan have healing effects on the kidney tissues of STZ- induced diabetic rats.


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