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Fırat Tıp Dergisi |
2008, Cilt 13, Sayı 1, Sayfa(lar) 001-004 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Testicular SOD, GSH-Px and MDA Levels in Experimental Toxicity of Formaldehyde and Protective Effect of ω-3 Fatty Acids |
İlter KUŞ1, İsmail ZARARSIZ1, Murat ÖGETÜRK1, H. Ramazan YILMAZ2, Mustafa SARSILMAZ1 |
1Fırat Üniversitesi Tıp Fakültesi Anatomi Anabilim Dalı, ELAZIĞ 2Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı, ISPARTA |
Objective: In this study, it was aimed to investigate the effects of formaldehyde toxicity on the testes at biochemical level. Potential antioxidant effects of ω-3 fatty acids against these toxic effects were also evaluated.
Materials and Methods: In our study, a total of 21 adult male Wistar rats were divided into three equal groups. Rats in group I were used as control. Rats in group II were injected intraperitoneally with formaldehyde every other day while the other ones received ω-3 fatty acids daily via intragastric gavage (Marincap capsule®) with injections of formaldehyde. At the end of 14-days experimental period, all animals were killed by decapitation and their testes were removed. Afterwards, the activites of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the level of malondialdehyde (MDA) in testicular tissue specimens were determined spectrophotometrically. Results: Biochemical values of group-treated formaldehyde alone showed that the enzymatic activities of testicular SOD and GSH-Px were significantly decreased compared to control values, while testicular MDA levels were significantly increased. On the other hand, it was found that there were increases in SOD and GSH-Px enzyme activities, and decreases in MDA levels in testis specimens of rats administered ω-3 fatty acids with exposure of formaldehyde. Conclusions: In this study performed on rats, it was determined biochemically that oxidative tissue damage in testes resulting from experimental toxicity of formaldehyde was prevented by omega-3 fatty acids.. ©2008, , Firat University, Medical Faculty |
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