Objective: The aim of this study is to investigate the effect of tolterodine tartarate on mucociliary clearance time.

Material and Method: Mucociliary clearance time of patients planned to receive tolterodine tartarate with a diagnosis of overactive bladder before treatment and after a 6-month treatment period were measured. Saccharine test was used to measure nasal mucociliary clearance time.

Results: The mean mucociliary clearance time of patients before treatment was 8.65±1.29 minutes,whereas it was7.80±1.29 minutes after treatment. After treatment a statistically significant increase in mucociliary clearance time was observed (p=0.022).

Conclusion: The patients using tolterodine tartarate must be followed up for sinonasal and middle ear infections.