Objective: In our study, we tried to present the relation of Helicobacteria pylori and hyperemesis gravidarum.

Material and Method: 82 pregnancies complicated with hyperemesis gravidarum and 98 pregnancies controls were studied. In both groups Helicobacteria pylori IgG and Helicobacteria pylori Cytotoxin-associated gene A (Cag A) were studied by ELISA.

Results: As a result we did not find any statistical significancy of seropositivity between hiperemezis gravidarum and control groups. In Turkey it seems to the non practical and expensive to scan or eradicate Helicobacteria pylori.

Conclusion: In high risk population (previous hyperemesis gravid arum or evident gastrointestinal symptoms), on the other hand, Helicobacteria pylori specific antibody scanning and appropriate therapy before pregnancy and follow up the family may be feasible.